The problem I have with the Lutron GE is the ugly factor. It's the size of a bank of switches.
Here is the Lutron GE master thread at AVS.
If you want to get rid of switch banks, then spend the money and home run the loads. Vantage, Lutron, Centralite, and LiteTouch make control systems for home-run loads. It's not a novel concept.
Call a local Lutron HomeWorks dealer and ask to see a demo. These systems are designed for easy integration into whole-house control systems. They are more expensive than your average lighting control system. If you want cheaper, look at LiteTouch and Centralite and avoid HW and Vantage.
If esthetics are most important, use Lutron HW. Best selection of colors, finishes, engraving, and form factors for keypad controls. GrafikEye control is an option with HW. The newest HomeWorks system is called HW QS.
HomeWorks Design & Style Guide
http://www.lutron.com/TechnicalDocumentLibrary/367-2017a.pdf
Since you were asking about security systems, I'll mention that security can be tied into lighting - exterior lights flash when alarm goes off, exterior motion detectors tied into exterior lights, arming security system can turn lights off, turn all the lights on or off (or any combination) from a bedside tabletop keypad, 'vaction mode' where your lights turn on and off when you're on vacation, and exit pathway lit for smoke alarm. Of course, most automated lighting systems are capable of these functions.
Edit - HomeWorks can also be used with a conventional wiring configuration. You could consider a hybrid system with HomeWorks - home-run the loads where esthetics are most important.