It certainly can be set up to make Elk annoucements through a whole house system. The main question is: is it worth the hassle?
I think the biggest issue that need to be addressed is if using the whole house audio system, you need to make sure it is quick enough to change inputs so as to not cut off any of the ELK annoucement. I think this is probably the hardest part of the whole project. It the whole house system has a paging input, then it would be relatively easy to close an Elk output just prior to any voice annoucement and that would trigger the whole house system to change over to the paging input.
The other concern is if there is a power outage, then you potentially loose your main source of annoucements. If you use the ELK speakers and a properly designed system, it can all run off battery power during an outage. Of course having the whole house system on a UPS cuts this down some, but I think you'll still want some ELK speakers in strategic locations as a failsafe backup.
I've looked into using the Elk three zone two way communication board to provide up to three zones of outputs using ELK speakers. I personally like this idea because I can cheaply have zones and build some logic in to prevent normal annoucements going to certain zones at certain periods of time (like the kids rooms at night). This can be done using some relays to turn on and off each zone as needed.
Just my 2 cents.